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  • Title: The prognostic significance of HPA-axis disturbance in panic disorder: a three-year follow-up.
    Author: Coryell W, Noyes R, Reich J.
    Journal: Biol Psychiatry; 1991 Jan 15; 29(2):96-102. PubMed ID: 1995088.
    Abstract:
    Seventy-seven patients with DSM-III panic disorder underwent a baseline dexamethasone suppression test (DST), participated in an 8-week controlled treatment trial, and provided follow-up interviews 2-4 years later. The 20 patients who had exhibited DST nonsuppression at baseline had more symptoms of anxiety, more work and social disability, and a greater likelihood of ongoing major depression than did patients who had had normal DST results. DST nonsuppression in panic disorder apparently indicates a more persistent and chronically disabling condition.
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