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Title: Development of an oxazole conjunctive reagent and application to the total synthesis of siphonazoles. Author: Zhang J, Polishchuk EA, Chen J, Ciufolini MA. Journal: J Org Chem; 2009 Dec 04; 74(23):9140-51. PubMed ID: 19950882. Abstract: The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.[Abstract] [Full Text] [Related] [New Search]