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  • Title: Human telomeric G-quadruplex: structures of DNA and RNA sequences.
    Author: Phan AT.
    Journal: FEBS J; 2010 Mar; 277(5):1107-17. PubMed ID: 19951353.
    Abstract:
    Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.
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