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  • Title: The Fisher variant of Guillain-Barré syndrome (Fisher syndrome).
    Author: Snyder LA, Rismondo V, Miller NR.
    Journal: J Neuroophthalmol; 2009 Dec; 29(4):312-24. PubMed ID: 19952907.
    Abstract:
    Fisher syndrome (FS) is an acute polyneuropathy typically characterized by the triad of ataxia, areflexia, and ophthalmoplegia, although it may present with 2 or even just 1 of these clinical findings. Similarities between FS and other acute polyneuropathies such as Guillain-Barré syndrome (GBS) and Bickerstaff brainstem encephalitis (BBE) suggest that FS is part of a spectrum of autoimmune disorders that may affect the peripheral and/or central nervous system. Anti-GQ1b antibody is present in the serum of more than 85% of patients with FS, but it is not specific to FS. Why some patients develop FS and others develop typical GBS or one of its other variants is still largely unknown.
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