These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Breakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation.
    Author: Mousset S, Bug G, Heinz WJ, Tintelnot K, Rickerts V.
    Journal: Transpl Infect Dis; 2010 Jun; 12(3):261-4. PubMed ID: 19954497.
    Abstract:
    Antifungal prophylaxis with posaconazole (POS) has been shown to decrease the mortality associated with invasive fungal infections in high-risk patients. We report on a patient, with severe graft-versus-host disease after allogeneic stem cell transplantation, who developed proven pneumonia due to Rhizopus microsporus after 40 days of POS prophylaxis (fasting serum levels: 691-904 ng/mL). Despite combination treatment with liposomal amphotericin B and POS for 39 days, the patient died from pulmonary hemorrhage. This case highlights the need for continued awareness of breakthrough zygomycosis in patients receiving POS.
    [Abstract] [Full Text] [Related] [New Search]