These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pitfalls in the diagnosis of central adrenal insufficiency in children.
    Author: Kazlauskaite R, Maghnie M.
    Journal: Endocr Dev; 2010; 17():96-107. PubMed ID: 19955760.
    Abstract:
    The diagnosis of central adrenal insufficiency relies heavily on laboratory testing of cortisol levels in the systemic circulation. The lack of cortisol assay standardization challenges the reliability of dynamic tests of the hypothalamic-pituitary adrenal axis. Although the insulin-induced hypoglycemia or metyrapone tests remain the accepted standards for evaluating central adrenal insufficiency in children their associated risks and inconvenience make them unattractive for routine use. Corticotropin testing is an effective first step to evaluate for chronic central adrenal insufficiency for children older than 2 years who are ambulatory, have normal sleep-wake cycle and normal serum protein levels. The low-dose (1 microg) corticotropin test may be superior to standard-dose (250 mcg) for patients with suspected hypothalamic-pituitary disease.
    [Abstract] [Full Text] [Related] [New Search]