These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Spinal cord compression and extramedullary hematopoiesis in young Egyptian beta-thalassemia patients.
    Author: Tantawy AA, Adly AA, Mahdy SA, Kamel GZ.
    Journal: Hemoglobin; 2009; 33(6):448-62. PubMed ID: 19958190.
    Abstract:
    The problem of spinal cord compression (SCC) related to extramedullary hematopoiesis (EMH) in beta-thalassemia (beta-thal) patients, both clinically and radiologically and its correlation with laboratory parameters of anemia and hemosiderosis was assessed. Sixty beta-thal patients were included and divided into group I: 40 beta-thal major patients (beta-TM), aged 7-30 years with a mean age of 15 +/- 5.3 years, group II: 20 beta-thal intermedia patients (beta-TI) aged 6-20 years with a mean age of 13 +/- 4.6 years. They were subjected to neurological examination, thoracic and lumbosacral computed tomography (CT) and magnetic resonance imaging (MRI). Spinal EMH was found in 13.3% of the thalassemic patients with a higher incidence in beta-TI compared to beta-TM patients (p = 0.03). Evidence of spinal EMH was associated with higher serum ferritin (p < 0.0001), lower pre transfusion hemoglobin (Hb) (p = 0.002) and lower transfusion index (p = 0.01). Extramedullary hematopoiesis was more evident in young beta-TI patients, and was related to inadequate chelation, high serum ferritin and inadequate transfusion therapy.
    [Abstract] [Full Text] [Related] [New Search]