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Title: Serum chitotriosidase activity and Wegener's granulomatosis. Author: Koening CL, Gota CE, Langford CA, Hoffman GS, Natowicz MR. Journal: Clin Biochem; 2010 Mar; 43(4-5):512-4. PubMed ID: 19958755. Abstract: OBJECTIVE: We evaluated serum chitotriosidase activity in patients with Wegener's granulomatosis (WG) and compared the values to controls. DESIGN AND METHODS: We used a standard fluorometric assay to measure chitotriosidase enzyme activity. RESULTS: Serum chitotriosidase enzyme activity levels were higher in WG patients. We found no association between clinical disease activity and chitotriosidase enzyme activity. CONCLUSIONS: Serum chitotriosidase enzyme activity has limited utility as a biomarker in WG patients.[Abstract] [Full Text] [Related] [New Search]