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  • Title: [Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model].
    Author: Liu XJ, Jia Q, Wang CY, Wang NL.
    Journal: Zhong Yao Cai; 2009 Aug; 32(8):1252-5. PubMed ID: 19960950.
    Abstract:
    OBJECTIVE: To study the absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model. METHODS: The Caco-2 monolayer model was used to explore the effect of time and drug concentration on the absorption of puerarin and its nanoparticeles. The drug concentration was determined by high-performance liquid chromatography and the Papp was caculated. RESULTS: The puerarin-PLGA-NP could significantly improve the absorption of puerarin. Puerarin was not only absorbed simply through passive diffusion, but also had relations with high dispersion of nanoparticles, increase of affinity and interaction with intestinal mucous membrane. CONCLUSION: The main mechanism of puerarin and its nanoparticles across Caco-2 monolayer model is passive transference. Puerarin-NP could increase the absorption of the drug in intestinal epithlial.
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