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  • Title: Novel Chlamydia pneumoniae vaccine candidates confirmed by Th1-enhanced genetic immunization.
    Author: Li Y, Ahluwalia SK, Borovkov A, Loskutov A, Wang C, Gao D, Poudel A, Sykes KF, Kaltenboeck B.
    Journal: Vaccine; 2010 Feb 10; 28(6):1598-605. PubMed ID: 19961962.
    Abstract:
    Identification of highly immunogenic antigens is critical for the construction of an efficacious subunit vaccine against Chlamydia pneumoniae infections. A previous project used a genome-wide screen to identify 12 protective C. pneumoniae candidate genes in an A/J mouse lung disease model (Li et al. [14]). Due to insufficient induction of Th1 immunity, these genes elicited only modest protection. Here, we used the Escherichia coli heat-labile enterotoxin as a Th1-enhancing genetic adjuvant, and re-tested these 12 genes, in parallel with six genes identified by other investigators. Vaccine candidate genes cutE and Cpn0420 conferred significant protection by all criteria evaluated (prevention of C. pneumoniae-induced death, reduction of lung disease, elimination of C. pneumoniae). Gene oppA_2 was protective by disease reduction and C. pneumoniae elimination. Four other genes were protective by a single criterion. None of the six genes reported elsewhere protected by reduction of lung disease or elimination of C. pneumoniae, but three protected by increasing survival.
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