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  • Title: Two novel neo-clerodane diterpenoids from Scutellaria barbata.
    Author: Lee H, Kim Y, Choi I, Min BS, Shim SH.
    Journal: Bioorg Med Chem Lett; 2010 Jan 01; 20(1):288-90. PubMed ID: 19962306.
    Abstract:
    Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC(50) value of 41.4microM.
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