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  • Title: Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: utilization of chiral ketene from carbohydrate.
    Author: Banik BK, Banik I, Becker FF.
    Journal: Eur J Med Chem; 2010 Feb; 45(2):846-8. PubMed ID: 19962794.
    Abstract:
    We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here.
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