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  • Title: Deblurring molecular images using desorption electrospray ionization mass spectrometry.
    Author: Parry R, Galhena AS, Fernandez FM, Wang MD.
    Journal: Annu Int Conf IEEE Eng Med Biol Soc; 2009; 2009():6731-4. PubMed ID: 19963935.
    Abstract:
    Traditional imaging techniques for studying the spatial distribution of biological molecules such as proteins, metabolites, and lipids, require the a priori selection of a handful of target molecules. Imaging mass spectrometry provides a means to analyze thousands of molecules at a time within a tissue sample, adding spatial detail to proteomic, metabolomic, and lipidomic studies. Compared to traditional microscopic images, mass spectrometric images have reduced spatial resolution and require a destructive acquisition process. In order to increase spatial detail, we propose a constrained acquisition path and signal degradation model enabling the use of a general image deblurring algorithm. Our analysis shows the potential of this approach and supports prior observations that the effect of the sprayer focuses on a central region much smaller than the extent of the spray.
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