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  • Title: [A case of rectal GIST treated with imatinib mesylate neoadjuvant therapy to preserve the anus].
    Author: Sekoguchi S, Okuyama Y, Enoki Y, Kawakami T, Tomie A, Yamada N, Yoriki H, Fukui A, Hattori T, Kamata K, Tomatsuri N, Nakamura H, Sato H, Kimura H, Yoshida N, Shioaki Y, Fujimoto S.
    Journal: Nihon Shokakibyo Gakkai Zasshi; 2009 Dec; 106(12):1751-7. PubMed ID: 19966517.
    Abstract:
    A 64-year-old man was admitted to our hospital with anal pain on evacuation. MRI revealed a large rectal submucosal tumor, more than 6 cm in diameter. Fine needle histological diagnosis indicated GIST with moderate risk. The patient was treated with imatinib mesylate in order to preserve the anus. The anal pain and tumor size decreased. Trans-anal local excision was performed. This case suggests that imatinib mesylate can make it possible to treat large rectal GIST cases by preserving anus, if neoadjuvant chemotherapy can be effective.
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