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  • Title: Sinemet CR in Parkinson's disease.
    Author: Pfeiffer RF, Wilken KE, Glaeske CS, Hofman R.
    Journal: Nebr Med J; 1991 Jan; 76(1):8-10. PubMed ID: 1997878.
    Abstract:
    Sinemet CR, a controlled release carbidopa/levodopa preparation, was compared to conventional carbidopa/levodopa in a double blind, placebo-controlled trial. Comparable clinical benefits and adverse effects were noted with the two medications. However significantly less frequent dosing was necessary with Sinemet CR.
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