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  • Title: Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis.
    Author: Merilahti-Palo R, Söderström KO, Lahesmaa-Rantala R, Granfors K, Toivanen A.
    Journal: Ann Rheum Dis; 1991 Feb; 50(2):87-90. PubMed ID: 1998396.
    Abstract:
    Non-viable structures of Yersinia enterocolitica O:3 were shown at the site of inflammation within mononuclear cells in the synovial membrane of eight out of 10 patients with yersinia triggered reactive arthritis. An avidin-biotin-peroxidase complex method, with a rabbit antiserum specific for Y enterocolitica O:3, was used to visualise yersinia structures. All 13 control samples were negative except for one with non-specific mast cell staining. The findings emphasise the significance of foreign material in the initiation of synovitis in reactive arthritis.
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