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  • Title: Hormonal influences on RNA and DNA synthesis in developing rat brain.
    Author: Ardeleanu A, Sterescu N.
    Journal: Physiologie; 1977; 14(3):133-40. PubMed ID: 199914.
    Abstract:
    In recent years, authors' interest was focussed on the role of hormones in the brain biochemical maturation during the early postnatal life. One-day-old rats were used in the investigation of the following hormones: thyroxine (T4), hydrocortisone, aldosterone and ACTH, in unique or repeated administration. Dynamics of cerebral RNA and DNA synthesis, a realiable indicator of central nervous system (CNS) maturation, was investigated. Authors' research led to the following conclusions: In infant rats, cerebral RNA and DNA synthesis exhibits a continuous increase, with a peak between 7 and 14 days after birth. Hydrocortisone induces a significant inhibition of cerebral RNA and DNA synthesis, more important in 7-day-old rats. In ACTH-treated newborn rats, RNA and DNA synthesis presents a high stimulation in 7- and 14-day-old rats. Aldosterone elicits an enhancement of brain nucleic acid synthesis, more marked in 7- and 14-day-old rats. Thyroxine administration induces a marked stimulation of cerebral RNA and DNA synthesis, greatest at 7 and 14 days after birth. The results confirm the important, even decisive, role of endocrine secretions during the early postnatal life, as far as the subsequent individual development is concerned.
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