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  • Title: Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.
    Author: Grayzel A, Solomon A, Aranow C, Diamond B.
    Journal: J Clin Invest; 1991 Mar; 87(3):842-6. PubMed ID: 1999497.
    Abstract:
    There is evidence in both murine and human lupus that the production of anti-DNA antibodies may be triggered by environmental antigens. To explore this further, we studied the serum of 10 nonautoimmune individuals immunized with a polyvalent pneumococcal polysaccharide vaccine. All 10 patients showed a rise in the titer of antipneumococcal antibodies bearing an anti-DNA-associated idiotype. The antipneumococcal response was specific as no idiotypic antitetanus antibodies were detected. Furthermore, no anti-DNA antibodies were present in postvaccination sera. The molecular analysis of antipneumococcal and anti-DNA antibodies bearing a common idiotype will help elucidate how foreign antigen might lead to the production of anti-DNA antibodies in susceptible individuals.
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