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  • Title: Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography.
    Author: Qin C, Yang X, Feng J, Liu K, Liu J, Yan G, Zhu S, Xu M, Tian J.
    Journal: Opt Express; 2009 Nov 23; 17(24):21925-34. PubMed ID: 19997437.
    Abstract:
    Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging. In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi- or multi-spectral information, which not only can avoid the time-consuming mesh generation but also can reduce the ill-posedness of BLT effectively. In the algorithm, the reconstruction can be largely enhanced by an adaptive technology based on a posteriori error estimation. Finally, the numerical and physical phantom experiment results show that the bioluminescent source can be recovered accurately.
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