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  • Title: [Efficacy of two methods of administration of salbutamol-ipratropium bromide in asthma crises].
    Author: Ponce Castro H, Rodríguez Gaytán R, Rodríguez Orozco AR.
    Journal: Rev Alerg Mex; 2009; 56(5):149-53. PubMed ID: 19999017.
    Abstract:
    BACKGROUND: Asthma acute crisis is one of the most frequent pediatric emergencies. Quick treatment with an efficient inhaled therapy may diminish considerably the number of hospitalizations and time of crises. OBJECTIVE: To compare the efficacy of administration of salbutamol and ipratropium bromide by nebulization with supplementary oxygen vs salbutamol and ipratropium bromide administered in device of measured doses with space chamber for treatment of asthmatic crises in children. PATIENTS AND METHOD: 45 children from 1 to 12 years of age were randomly selected; they were divided into two groups and were classified according to respiratory difficulty degree. Then inhaled therapy proposed was administered three times, and oximetry and hospitalization criteria were determined. RESULTS: Pediatric patients with non-severe asthma crisis had a better course with salbutamol and ipratropium bromide combination administered by device of measures doses and space chamber than with the same drugs nebulized with supplementary oxygen, and percentage of hospitalizations of children with asthma crises was reduced (p = 0.037). CONCLUSION: Administration of salbutamol and ipratropium bromide with device of measured doses was more efficient that their administration nebulized with supplementary oxygen for treating asthmatic crises in children.
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