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  • Title: [Effects of sevoflurane versus target-controlled infusion of propofol on haemodynamics during elective breast surgery in healthy women].
    Author: Łasińska-Kowara M, Kardel-Reszkiewicz E, Owczuk R.
    Journal: Anestezjol Intens Ter; 2009; 41(3):135-9. PubMed ID: 19999599.
    Abstract:
    BACKGROUND: Haemodynamic changes during general anaesthesia are still being widely investigated. Although propofol and sevoflurane are commonly used anaesthetic agents, there is a lack of comparative studies assessing their influence on haemodynamic parameters. We have assessed whether the effects of target-controlled propofol anaesthesia on HR, MAP and cardiac output, are different from those seen with a sevoflurane-based protocol. METHODS: ASA I and II females, scheduled for elective breast surgery, were studied. After premedication with midazolam and intravenous induction with propofol, fentanyl and vecuronium bromide, general anaesthesia was maintained with either 1 MAC sevoflurane in oxygen/air (group S), or a target-controlled infusion of 3 micromL(-1) propofol (group P). Both groups received additional fentanyl. Heart rates and mean arterial pressures were noted and compared. Stroke volumes, cardiac outputs and cardiac indexes were measured every 3 min, using a non-invasive carbon dioxide rebreathing method (NICO). RESULTS: Fifty-seven patients were enrolled in the study. Comparisons between the groups revealed a significant decrease in mean heart rate during maintenance of anaesthesia with propofol (p<0.05), but not with sevoflurane. Although cardiac output and cardiac index were lower in group P towards the end of analysis, no statistically significant differences in HR, MAP, SV, CO or CI were found between the groups. CONCLUSION: The haemodynamic effect of a target 3 micromL(-1) propofol infusion did not differ significantly from that observed with 1 MAC sevoflurane.
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