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  • Title: [(13)C]Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.
    Author: Sternfeld T, Lorenz A, Schmid M, Schlamp A, Demmelmair H, Koletzko B, Bogner JR.
    Journal: AIDS Res Hum Retroviruses; 2009 Dec; 25(12):1243-8. PubMed ID: 20001311.
    Abstract:
    Metabolic disturbances such as dyslipidemia, lipodystrophy syndrome, visceral obesity, hyperlactatemia, diabetes mellitus, and hepatic steatosis have been recognized as serious complications in long-term antiretroviral-treated HIV-infected patients. The oxidative capacity of liver mitochondria plays a central role in their pathogenesis and can be analyzed using the [(13)C]methionine breath test. We analyzed hepatic mitochondrial function using the [(13)C]methionine breath test in antiretrovirally treated and untreated HIV-infected patients as well as HIV-negative controls. Patients with hepatic steatosis, hypertriglyceridemia, lipohypertrophy, and older age showed reduced methionine metabolism. Hepatic mitochondrial function is impaired in antiretroviral-treated HIV-infected patients with disturbances of lipid metabolism.
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