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  • Title: P53 deletion may drive the clinical evolution and treatment response in multiple myeloma.
    Author: López-Anglada L, Gutiérrez NC, García JL, Mateos MV, Flores T, San Miguel JF.
    Journal: Eur J Haematol; 2010 Apr; 84(4):359-61. PubMed ID: 20002730.
    Abstract:
    We report a patient with multiple myeloma presenting with a paraspinal plasmacytoma with a marked dissociation between the response obtained in bone marrow (BM) infiltration and that achieved in soft tissue masses. While a complete remission was reached and maintained in BM, extramedullary plasmacytomas were refractory to every line of treatment. Genetic analysis identified the presence of t(4;14) and RB deletion in myeloma cells of both origins. However, a P53 deletion was only detected in plasma cells from extramedullary plasmacytomas. This finding suggests that P53 deletion has a role in the lack of treatment response of extramedullary plasmacytomas.
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