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  • Title: Characterization of human serum albumin forms with pH. Fluorescence lifetime studies.
    Author: Amiri M, Jankeje K, Albani JR.
    Journal: J Pharm Biomed Anal; 2010 Apr 06; 51(5):1097-102. PubMed ID: 20005063.
    Abstract:
    Fluorescence lifetimes of human serum albumin (HSA) tryptophan 214 residue were measured in solution at different pH (from 2 to 12). The results indicate that tryptophan emission occurs with three lifetimes at all pH. However, lifetimes and pre-exponential values are dependent on the pH and thus on the protein form. Three different protein populations have been differentiated: one population for pH 2 and 3 (extended form), the second one from pH 4 to 9 containing HSA migrating (F), normal (N) and basic (B) forms. Another type of population is obvious for pH higher than 9, characterizing the aged (A) form of HSA.
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