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  • Title: Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents.
    Author: Lee MY, Kim MH, Kim J, Kim SH, Kim BT, Jeong IH, Chang S, Kim SH, Chang SY.
    Journal: Bioorg Med Chem Lett; 2010 Jan 15; 20(2):541-5. PubMed ID: 20005100.
    Abstract:
    Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
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