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  • Title: Synthesis and in vivo evaluation of bicyclic gababutins.
    Author: Blakemore DC, Bryans JS, Carnell P, Carr CL, Chessum NE, Field MJ, Kinsella N, Osborne SA, Warren AN, Williams SC.
    Journal: Bioorg Med Chem Lett; 2010 Jan 15; 20(2):461-4. PubMed ID: 20005103.
    Abstract:
    Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (-)-(11A) and (20A) which both had an excellent level of potency against alpha(2)delta and were profiled in an in vivo model of neuropathic pain.
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