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  • Title: Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
    Author: Yamaji Y, Sakurai K, Hamada K, Komatsu K, Ozeki J, Yoshida A, Yoshii A, Shimizu T, Namba S, Hibi T.
    Journal: Arch Virol; 2010 Feb; 155(2):263-8. PubMed ID: 20012112.
    Abstract:
    Eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with both the viral RNA-dependent RNA polymerase and the 3'-terminal genomic RNA of tobacco mosaic virus (TMV). In this study, we demonstrated that the down-regulation of eEF1A mRNA levels by virus-induced gene silencing using potato virus X vector dramatically reduced the accumulation of TMV RNA and the spread of TMV infection. The translation activity of the eEF1A-silenced Nicotiana benthamiana leaves was not severely affected. Collectively, these results suggest an essential role of eEF1A in TMV infection.
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