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  • Title: Release of vasoactive peptides from autonomic and sensory nerves.
    Author: Lundberg JM, Franco-Cereceda A, Lacroix JS, Pernow J.
    Journal: Blood Vessels; 1991; 28(1-3):27-34. PubMed ID: 2001477.
    Abstract:
    Release of specific vasoactive peptides occurs upon activation of perivascular parasympathetic (vasoactive intestinal polypeptide and peptide histidine isoleucine), sympathetic (neuropeptide Y) and sensory (calcitonin gene-related peptide and tachykinins) nerves. These peptides may serve as cotransmitters with acetylcholine and noradrenaline with interactions both at the pre- and postjunctional levels. Some long-lasting nonadrenergic, noncholinergic vascular effects upon nerve activation may thus be peptide-mediated. Strong activation seems to be necessary for peptidergic transmission in the parasympathetic and sympathetic system while local sensory mechanisms may occur even at single impulses.
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