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  • Title: Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.
    Author: Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.
    Journal: Proc Natl Acad Sci U S A; 2010 Jan 05; 107(1):395-400. PubMed ID: 20018684.
    Abstract:
    Bipolar cells are the central neurons of the retina that transmit visual signals from rod and cone photoreceptors to third-order neurons in the inner retina and the brain. A dogma set forth by early anatomical studies is that bipolar cells in mammalian retinas receive segregated rod/cone synaptic inputs (either from rods or from cones), and here, we present evidence that challenges this traditional view. By analyzing light-evoked cation currents from morphologically identified depolarizing bipolar cells (DBCs) in the wild-type and three pathway-specific knockout mice (rod transducin knockout [Tralpha(-/-)], connexin36 knockout [Cx36(-/-)], and transcription factor beta4 knockout [Bhlhb4(-/-)]), we show that a subpopulation of rod DBCs (DBC(R2)s) receives substantial input directly from cones and a subpopulation of cone DBCs (DBC(C1)s) receives substantial input directly from rods. These results provide evidence of the existence of functional rod-DBC(C) and cone-DBC(R) synaptic pathways in the mouse retina as well as the previously proposed rod hyperpolarizing bipolar-cells pathway. This is grounds for revising the mammalian rod/cone bipolar cell dogma.
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