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  • Title: Sinuladiterpenes A-F, new cembrane diterpenes from Sinularia flexibilis.
    Author: Lo KL, Khalil AT, Kuo YH, Shen YC.
    Journal: Chem Biodivers; 2009 Dec; 6(12):2227-35. PubMed ID: 20020460.
    Abstract:
    Chromatographic investigation of the octocoral Sinularia flexibilis afforded six new cembrane diterpenes, sinuladiterpenes A-F (1-6, resp.), in addition to four known cembranolides, 11-episinulariolide acetate, 11-dehydrosinulariolide, 11-episinulariolide, and sinulariolide. Their structures were elucidated by spectroscopic analysis, especially 2D-NMR and HR-ESI-MS. Compound 2 exhibited significant in vitro cytotoxic activity against human colon adenocarcinoma (WiDr) cell line.
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