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  • Title: The insulin-like growth factor-1 axis and its potential as a therapeutic target in central nervous system (CNS) disorders.
    Author: Bibollet-Bahena O, Cui QL, Almazan G.
    Journal: Cent Nerv Syst Agents Med Chem; 2009 Jun; 9(2):95-109. PubMed ID: 20021343.
    Abstract:
    The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.
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