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  • Title: Epigenetics: molecular mechanisms and implications for disease.
    Author: Handel AE, Ebers GC, Ramagopalan SV.
    Journal: Trends Mol Med; 2010 Jan; 16(1):7-16. PubMed ID: 20022812.
    Abstract:
    Epigenetics is rising to prominence in biology as a mechanism by which environmental factors have intermediate-term effects on gene expression without changing the underlying genetic sequence. This can occur through the selective methylation of DNA bases and modification of histones. There are wide-ranging implications for the gene-environment debate and epigenetic mechanisms are causing a reevaluation of many traditional concepts such as heritability. The reversible nature of epigenetics also provides plausible treatment or prevention prospects for diseases previously thought hard-coded into the genome. Here, we consider how growing knowledge of epigenetics is altering our understanding of biology and medicine, and its implications for future research.
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