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  • Title: N-Heterocyclic carbene-catalyzed intramolecular aldehyde-nitrile cross coupling: an easy access to 3- aminochromones.
    Author: Vedachalam S, Zeng J, Gorityala BK, Antonio M, Liu XW.
    Journal: Org Lett; 2010 Jan 15; 12(2):352-5. PubMed ID: 20025237.
    Abstract:
    An immense effort has been made to develop an efficient strategy for the carbon-carbon bond formation between aldehyde and nitrile intramolecularly using an N-heterocyclic carbene catalyst to derive 3-aminochromone derivatives in good to excellent yields (80-95%).
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