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  • Title: Highly enantioselective titanium-catalyzed cyanation of imines at room temperature.
    Author: Seayad AM, Ramalingam B, Yoshinaga K, Nagata T, Chai CL.
    Journal: Org Lett; 2010 Jan 15; 12(2):264-7. PubMed ID: 20025268.
    Abstract:
    A highly active and enantioselective titanium-catalyzed cyanation of imines at room temperature is described. The catalyst used is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-beta-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields in 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.
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