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  • Title: Fetal autonomic response to severe acidaemia during labour.
    Author: van Laar JO, Peters CH, Vullings R, Houterman S, Bergmans JW, Oei SG.
    Journal: BJOG; 2010 Mar; 117(4):429-37. PubMed ID: 20025619.
    Abstract:
    OBJECTIVE: Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. DESIGN: Case-control study. SETTING: Obstetric unit of a tertiary-care teaching hospital. POPULATION: Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH < 7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. METHODS: Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. MAIN OUTCOME MEASURES: Absolute power and normalised power in the low-frequency and high-frequency bands. RESULTS: No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). CONCLUSION: The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition.
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