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  • Title: The role of genes in disease: beware of simplistic interpretations!
    Journal: Prescrire Int; 2009 Dec; 18(104):279-82. PubMed ID: 20027720.
    Abstract:
    (1) Most diseases with a strong genetic component and a Mendelian pattern of inheritance are rare or very rare disorders; (2) The most common human diseases result from complex interactions between genetic and environmental factors. They are multifactorial; (3) The simple presence of genes that are associated with a disease is not generally sufficient to determine with certainty that the signs and symptoms that characterise the disease will develop in that individual; (4) The association of a disease with a gene does not mean that the gene causes the disease.
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