These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles].
    Author: Zhao J, Liu Z, Xu J, Yu Y, Feng N.
    Journal: Zhongguo Zhong Yao Za Zhi; 2009 Sep; 34(18):2322-4. PubMed ID: 20030079.
    Abstract:
    OBJECTIVE: To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs). METHOD: The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively. RESULT: The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment. CONCLUSION: The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
    [Abstract] [Full Text] [Related] [New Search]