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  • Title: [Preparation and drug release property of paclitaxel nanoparticles].
    Author: Wang TW, Wu Y, Li MJ, Gao HX.
    Journal: Zhong Yao Cai; 2009 Sep; 32(9):1447-9. PubMed ID: 20034226.
    Abstract:
    OBJECTIVE: To prepare paclitaxel nanoparticles and evaluate its drug release property in vitro. METHODS: The chitosan-poly (lactide) copolymers were synthesized by ring-opening polymerization. Paclitaxel nanoparticles were prepared by the nanoprecipitation method. The encapsulation efficiency of the nanoparticles and the in vitro release of paclitaxel were studied. RESULTS: The nanoparticles were fine and uniform spheres. The encapsulation efficiency of nanoparticles was up to 93.2%. The in vitro release profile showed the slow and stable release rate of paclitaxel. CONCLUSION: This method is simple and the nanoparticles possess good physical performance as sustained release character in vitro.
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