These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The gelsolin:calponin complex nucleates actin filaments with distinct morphologies.
    Author: Ferjani I, Fattoum A, Bettache N, Seantier B, Milhiet PE, Manai M, Benyamin Y, Roustan C, Maciver SK.
    Journal: Biochem Biophys Res Commun; 2010 Feb 05; 392(2):118-23. PubMed ID: 20035726.
    Abstract:
    Gelsolin and calponin are cytoskeletal and signalling proteins that form a tight 1:1 complex (GCC). We show that calponin within the GCC inhibits the rate of gelsolin mediated nucleation of actin polymerization. The actin-binding function of calponin is ablated within the GCC as the actin-binding site overlaps with one of the gelsolin binding sites. The structure of filaments that result from nucleation by GCC are different to those nucleated by gelsolin alone in that they are longer, loosely bundled and stain heterogeneously with phalloidin. GCC nucleated filaments appear contorted and wrap around each to form the loose bundles.
    [Abstract] [Full Text] [Related] [New Search]