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  • Title: Performance evaluation of a particle-enhanced turbidimetric cystatin C assay using the Abbott Aeroset analyser and assessment of cystatin C-based equations for estimating glomerular filtration rate in chronic kidney disease.
    Author: Sun Y, Jiang T, Zeng Z, Chen P.
    Journal: Nephrol Dial Transplant; 2010 May; 25(5):1489-96. PubMed ID: 20037185.
    Abstract:
    INTRODUCTION: Measurement of glomerular filtration rate (GFR) is critical for the diagnosis and stratification of chronic kidney disease (CKD). Recent studies have shown that cystatin C is superior to creatinine for the detection of impaired GFR, and several cystatin C-based equations for estimating GFR have been developed for this clinical application. We conducted the present study to assess the applicability of cystatin C as a routine clinical laboratory index and to determine the performance of cystatin C-based equations in estimating GFR in CKD patients in China. METHODS: Performance evaluation of particle-enhanced turbidimetric cystatin C assay on the Abbott Aeroset analyser was carried out according to the National Committee for Clinical Laboratory document EP10-A2. Estimated GFR, which was generated from cystatin C-based equations, was compared with measured GFR, which was detected by plasma clearance of 99mTc-DTPA. RESULTS: Our cystatin C assay showed a very low total imprecision and linearity drift. All eight cystatin C-based GFR estimating equations underestimated or overestimated GFR as compared with GFR determined by 99mTc-DTPA clearance. CONCLUSION: Although the cystatin C assay is acceptable for routine clinical laboratory monitoring, none of the existing cystatin C-based equations were ideal for estimating GFR in Chinese CKD patients.
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