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  • Title: [Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer].
    Author: Sakurai K, Matsuo S, Enomoto K, Tani M, Kitajima A, Amano S.
    Journal: Gan To Kagaku Ryoho; 2009 Nov; 36(12):1991-3. PubMed ID: 20037301.
    Abstract:
    We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.
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