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  • Title: [A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus].
    Author: Hatano H, Kobayashi S, Nagano H, Tomokuni A, Tomimaru Y, Murakami M, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Wakasa K, Doki Y, Mori M.
    Journal: Gan To Kagaku Ryoho; 2009 Nov; 36(12):2374-6. PubMed ID: 20037427.
    Abstract:
    We report a case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus. A 66-year-old man was diagnosed with hepatocellular carcinoma with Vp3 by abdominal enhanced CT. He underwent a complete tumor resection and following interferon and 5-FU combined intra-arterial chemotherapy as an adjuvant setting. The histological findings were consistent with combined hepatocellular and cholangiocarcinoma. At 9 months after the surgery, lymph node metastases were detected. Then we started an oral fluoropyrimidine anticancer agent S-1, because the recurrence was suspected to be originated from the cholangiocarcinoma component. Thereafter, sustained partial remission was achieved. In case of combined hepatocellular and cholangiocarcinoma, we need to create a treatment strategy against characteristics of both components.
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