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  • Title: The mechanism of action of glatiramer acetate treatment in multiple sclerosis.
    Author: Racke MK, Lovett-Racke AE, Karandikar NJ.
    Journal: Neurology; 2010 Jan 05; 74 Suppl 1():S25-30. PubMed ID: 20038760.
    Abstract:
    OBJECTIVE: Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. METHODS: We review the various mechanisms that have been proposed for this random polymer over the years, with emphasis on recent methods that utilize modern immunologic techniques. RESULTS: Studies describing processes such as immune deviation and effects on regulatory T cells and antigen-presenting cells are presented. CONCLUSIONS: Effects of glatiramer acetate on the immune response have evolved as our technical abilities and knowledge of the immune response itself have developed.
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