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  • Title: Vascular smooth muscle contraction/relaxation of rat carotid artery is not altered by bone grafting substitutes in vitro.
    Author: Ertan AA, Beriat NC, Gürpinar A, Onur MA, Cehreli MC.
    Journal: Oral Maxillofac Surg; 2010 Jun; 14(2):97-104. PubMed ID: 20039182.
    Abstract:
    PURPOSE: The aim of this study was to explore the effects of various bone grafting substitutes (Osteosponge, Perioglas, Tutoplast, and Surgibone) on vascular smooth muscle tonus. METHODS: Bilateral carotid arteries were removed from rats and contraction/relaxation of isolated vessel rings were measured before and after contact with the biomaterials and then, for dose-dependent epinephrine and papaverin administrations, by a force displacement transducer. The data of each biomaterial group were collected by a computerized system and corresponding software at a sample rate of 1,000 kHz and were converted to contraction force. RESULTS: Vascular contraction forces were influenced in response to biomaterials tested except for Osteosponge (P < 0.05), although the differences between groups were insignificant (P > 0.05). There was a dose-dependent vascular response to epinephrine and papaverine administration upon biomaterial contact (P < 0.05). The dose-dependent vascular responses to epinephrine and papaverine administration were almost similar for all biomaterials tested (P < 0.05), suggesting that the biomaterials led to reversible effects on vascular contraction/relaxation behavior, which resulted in recovery. CONCLUSIONS: Osteosponge, Perioglas, Tutoplast, and Surgibone do not alter vascular smooth muscle tonus and vitality and therefore would, presumably, not jeopardize the angiogenesis of fresh blood vessels and full vascularization during tissue healing.
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