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  • Title: Dynamic kinetic asymmetric transformation (DYKAT) by combined amine- and transition-metal-catalyzed enantioselective cycloisomerization.
    Author: Zhao GL, Ullah F, Deiana L, Lin S, Zhang Q, Sun J, Ibrahem I, Dziedzic P, Córdova A.
    Journal: Chemistry; 2010 Feb 01; 16(5):1585-91. PubMed ID: 20039352.
    Abstract:
    The first examples of one-pot highly chemo- and enantioselective dynamic kinetic asymmetric transformations (DYKATs) involving alpha,beta-unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd(0)-catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes with up to 99 % ee and can be used for the generation of all-carbon quaternary stereocenters.
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