These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Renal 11 beta-hydroxysteroid dehydrogenase activity: effects of age, sex and altered hormonal status.
    Author: Smith RE, Funder JW.
    Journal: J Steroid Biochem Mol Biol; 1991 Feb; 38(2):265-7. PubMed ID: 2004048.
    Abstract:
    The enzyme 11 beta-hydroxysteroid dehydrogenase, by converting cortisol and corticosterone to their receptor-inactive 11-keto metabolites cortisone and 11-dehydrocorticosterone, appears crucial to the aldosterone-selectivity of renal mineralocorticoid receptors. Levels of enzyme activity in the rat kidney, measured by conversion of cortisol to cortisone, are unaltered by changes in adrenal or thyroid status, or by castration in either sex; in contrast, oestrogen administration increases enzyme activity in male rats.
    [Abstract] [Full Text] [Related] [New Search]