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  • Title: Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals.
    Author: Malairajan P, Gopalakrishnan G, Narasimhan S, Veni KJ.
    Journal: Indian J Pharmacol; 2008 Jun; 40(3):126-8. PubMed ID: 20040940.
    Abstract:
    OBJECTIVE: To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites. MATERIALS AND METHODS: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o. RESULTS: A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer. CONCLUSION: This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.
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