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  • Title: Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles.
    Author: Nguyen CT, Nguyen JT, Rutledge S, Zhang J, Wang C, Walker GC.
    Journal: Cancer Lett; 2010 Jun 01; 292(1):91-7. PubMed ID: 20042272.
    Abstract:
    Selective targeting and detection of a hematologic malignancy, chronic lymphocytic leukemia, using surface enhanced Raman scattering (SERS) gold nanoparticles is reported. The functional nanoparticles were composed of a gold core onto which an optical reporter dye was adsorbed, protected from aggregation by grafted polyethyleneglycol, and targeted to CD19 antigen by antibodies. The signals were detected by dark-field microscopy and Raman spectrometry. The observation that the Raman signals are not disrupted by several traditional pathology stains indicates advantages over fluorescence methods.
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