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  • Title: Meningeal involvement in Bence Jones multiple myeloma.
    Author: Oda K, Egawa H, Okuhara T, Sakai A, Hyohdou H, Tanaka H, Kuramoto A.
    Journal: Cancer; 1991 Apr 01; 67(7):1900-2. PubMed ID: 2004303.
    Abstract:
    A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64-year-old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.
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