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  • Title: The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.
    Author: Huigens RW, Reyes S, Reed CS, Bunders C, Rogers SA, Steinhauer AT, Melander C.
    Journal: Bioorg Med Chem; 2010 Jan 15; 18(2):663-74. PubMed ID: 20044260.
    Abstract:
    Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.
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